Plenary Session II Agenda
Presiders: Kurt Lu, MD and Peggy Myung, MD/PhD
3:30 PM-3:45 PM
#561, Development and first-in-human characterization of a potent oral CCR4 antagonist for the treatment of atopic dermatitis
- L.E. Cheng, A.Jorapur, S. Jacobson, O.Talay, S. Miakicheva, D. Trujillo, N. Lee, J. Jankicevic, D. Wustrow, P. Kassner, W. Ho, D. Brockstedt
RAPT Therapeutics, Inc., South San Francisco, California, United States
3:45 PM -4:00 PM
#327 , Staphylococcus epidermidis protease EcpA is a deleterious component of the skin microbiome in atopic dermatitis
- L. Cau1, 2, M. Williams1, A. Butcher1, T. Nakatsuji1, J. Cheng1, T. Hata1, J. Kavanaugh3, C. Mainzer2, B. Closs2, A. Horswill3, R. L. Gallo1
1Dermatology Department, University of California, San Diego, California, United States, 2R&D Department, SILAB, Brive, France, 3Immunology and Microbiology Department, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
4:00 PM-4:15 PM
#717, Enhanced molecular signatures in cutaneous lupus erythematosus patients support distinct pathogenic pathways in African American patients
- J. L. Zhu1, L. Tran2, F. Zheng2, J. James2, J. Guthridge2, B. F. Chong1
1Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States
4:15 PM-4:30 PM
#775, Hyperactivation of sympathetic nerves drives melanocyte stem cell depletion
- B. Zhang1, S. Ma1, 2, 3, I. Rachman4, M. He1, 5, P. Baral6, S. Choi1, W. A. Gonçalves10, Y. Shwartz1, E. M. Fast1, 7, Y. Hsu4, L. I. Zon1, 7, 8, A. Regev2, 8, 3, J. D. Buenrostro1, T. M. Cunha6, 9, I. M. Chiu6, D. Fisher4, Y. Hsu1
1Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States, 2Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States, 3Department of Biology and Koch Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States, 4Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Charlestown, Massachusetts, United States, 5Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States, 6Department of Immunology, Harvard Medical School, Boston, Massachusetts, United States, 7Division of Hematology/Oncology, Boston Children’s Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts, United States, 8Howard Hughes Medical Institute, Chevy Chase, Maryland, United States, 9Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil, 10Graduate Program in Cellular Biology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil
4:30 PM-4:45 PM
#030, VGLL3, an orchestrator of female-biased autoimmunity, interfaces with the Hippo pathway to modulate genes involved in immunity and fibrosis
- A.C. Billi1, C. Zeng1, M. Gharaee-Kermani2, S. W. Stoll1, M. J. Wilson1, O. Plazyo1, X. Xing1, J. M. McCarthy1, L. C. Tsoi4, 5, J. Kahlenberg2, A. A. Dlugosz1, 3, J. E. Gudjonsson1
1Dermatology, University of Michigan, Ann Arbor, Michigan, United States, 2Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, United States, 3Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States, 4Biostatistics, University of Michigan, Ann Arbor, Michigan, United States, 5Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States